| Console: | Sega Game Gear |
| TV Standard: | Region Not Set |
| Developer(s): | Bits Studios |
| Publisher(s): | Flying Edge, Inc. |
| Release Date: | 1993-01-01 |
| Co-op: | No |
| Type: | Platform |
Doctor Octopus™ is planning the crowning caper of his criminal career... to RULE THE WORLD! He has reunited The Sinister Six™: Electro™, Sandman™, Mysterio™, The Vulture™ and Hobgoblin™. Nothing stands in the way of these reunited Super Villains... except your friendly neighborhood Spider-Man®!
Game Player of Spider-Man: Return of the Sinister Six on Sega Game GearGenerally, you can review the controls (keyboard) setting during each game in the screen before it starts. Use the arrow keys and “Z”, “X”, “A”, “S”, “Q”, “E” buttons to play, or customize yourself with your gamepad or keyboard.
| Keyboard | Controls |
| ← → ↑ ↓ | Directions for LEFT, RIGHT, UP, DOWN |
| Enter ↵ | START |
| Shift | SELECT |
| Z | A |
| X | B |
| A | X |
| S | Y |
| Q | L |
| E | R |
