Spider-Man 2

The plot of the PC game differs drastically from the main console versions. It first starts out with a short cutscene from the primary console game that introduces as to how Dr. Otto Octavius became Doctor Octopus with his fusion reaction experiment. The PC version then diverges from the console versions with a tutorial, (narrated by Bruce Campbell) telling the player how to play as Spider-Man, (i.e. web swinging, wall crawling, fighting, etc.).

The storyline for the game starts off with a cutscene of a gray van being chased down by the police before it crashes, and out come two crooks. Spider-Man dispatches the crooks quickly, but the van drives away automatically. Spider-Man follows it to the New York Maximum Security Prison where a large group of thugs are causing a riot. Spider-Man defeats many crooks and escaping prisoners before the Rhino busts out of the prison. He briefly fights Spider-Man before he tries to charge away, but he is caught in a laser cage set up by the police. Deciding to let the undefeated prisoners escape (whom he can later find in alleys and hidden areas), Spider-Man goes after the Rhino and defeats him by making him charge into the laser field (and subsequently pummel him while he is down, which is an option and it makes the Rhino's defeat quicker). Just before he is defeated, the Rhino charges at Spider-Man one last time and escapes the laser field, but he accidentally rams into a gas station that blows up and knocks him several blocks away from the explosion, where Doctor Octopus takes his unconscious form. Spider-Man lets Doctor Octopus get away with Rhino while he douses the fires caused by the explosion and then demonstrates a new power punch by defeating three crooks (these power punches are gained when defeating normal enemies, not bosses, and once they are gained, they drain out during combat, which quickly defeats enemies with a single punch).

Later, Peter Parker, Spider-Man's alter ego, is with his Aunt May at the bank, and goes to the bathroom just as Doctor Octopus and a gang of his robbers hold the bank hostage. Spider-Man pummels his way through the robbers and saving the hostages, including Aunt May, until he reaches the basement of the bank where he confronts Doctor Octopus. They fight, but Doctor Octopus gets away with his stolen cash. Spider-Man once again lets him get away in order to save Aunt May from a band of three robbers who kidnap her and take her into their van. Spider-Man stops the van, dispatches the robbers and saves Aunt May.

The next day, Peter is walking with Mary Jane Watson through the city when they both spot MJ's car getting stolen. Peter tells MJ to wait where she is while he calls the police. Then Spider-Man follows the car to a garage where he confronts the villain Puma and a band of his crooks in a warehouse. Puma leads Spider-Man on a chase throughout the warehouse while Spider-Man pummels his way through Puma's cronies, and their initial fight takes place in a small room. After Puma takes some beating, he takes the fight outside to the rooftops, at a water fountain and finally to an unfinished construction site. There, Puma finally surrenders in his fight against Spider-Man, but gleefully tells him that he was merely a distraction for Spider-Man while Doctor Octopus kidnapped Mary Jane. In a cutscene, Puma tries to get away but Spider-Man webs him up and finally defeats Puma. He calls Mary Jane, but Doctor Octopus has kidnapped her.

Later, Doctor Octopus and his cronies attack OsCorp. Spider-Man goes to OsCorp to foil the heist there, defeating many cronies and saving countless civilians and scientists, as well as disabling the eight bombs Doctor Octopus placed in the building. Spider-Man is then confronted by Rhino in a room with six generators which Spider-Man makes the brutish villain ram into and electrocute himself, but Rhino is not done yet. He confronts Spider-Man for a third time in a room with four liquid nitrogen tubes that Spider-Man destroys and leaks the gases in the tubes, quickly freezing the room. But Spider-Man escapes the room before it freezes and Rhino is frozen with it, finally defeating him. Then Spider-Man leaves OsCorp through an elevator to continue his search for Doctor Octopus on OsCorp's rooftop before he finds himself in a New York literally torn out of the ground and into the sky by the machinations of the supervillain Mysterio, who has done this to further Doctor Octopus's plans.

Spider-Man destroys the generators that seemingly hold New York in the sky, as well as fighting through Mysterio's numerous robots, before fighting and chasing a flying Mysterio himself, which Spider-Man fights back by throwing meteors at the villain that the latter throws down from the sky to defeat the superhero. But Mysterio is not done yet; he tries to kill Spider-Man again with a giant laser gun on top of the Daily Bugle, but Spider-Man destroys it and defeats Mysterio. Mysterio tells Spider-Man of Doctor Octopus's plans and disappears, reverting New York back to normal.

Spider-Man takes the final fight to Doctor Octopus through the subways, fighting past the remainder of Doctor Octopus's cronies, saving Mary Jane and battling Doctor Octopus in a final showdown at his fusion reactor. Spider-Man pummels enough sense into him to make Doctor Octopus realize the error of his ways and he sacrifices himself by pulling his machine in with him into the river (much like the movie), and Spider-Man escapes with Mary Jane without revealing his identity to her.