| Console: | Nintendo Entertainment System (NES) |
| TV Standard: | Region Not Set |
| Developer(s): | BITS |
| Publisher(s): | LJN |
| Release Date: | 1992-10-15 |
| Co-op: | No |
| Type: | Action |
Doctor Octopus is plotting the crowning caper of his criminal career... to rule the world. He has reunited the Sinister Six and with these super-villains together again, nothing stands in their way - except Spider-Man!
Game Player of Spider-Man: Return of the Sinister Six on Nintendo Entertainment System (NES)Generally, you can review the controls (keyboard) setting during each game in the screen before it starts. Use the arrow keys and “Z”, “X”, “A”, “S”, “Q”, “E” buttons to play, or customize yourself with your gamepad or keyboard.
| Keyboard | Controls |
| ← → ↑ ↓ | Directions for LEFT, RIGHT, UP, DOWN |
| Enter ↵ | START |
| Shift | SELECT |
| Z | A |
| X | B |
| A | X |
| S | Y |
| Q | L |
| E | R |
